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znuB [2019-06-18 10:33:29]
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znuB [2019-06-18 10:33:29]

high-affinity ABC transporter for zinc (permease)
Locus
BSU02870
Isoelectric point
10.38
Molecular weight
30.28 kDa
Protein length
280 aa Sequence Blast
Gene length
843 bp Sequence Blast
Function
zinc uptake
Product
ABC transporter for zinc (permease)
Essential
no
Synonyms
yceA
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Cellular processes → Transporters → ABC transporters → Importers → Uptake of ions
  • Cellular processes → Homeostasis → Trace metal homeostasis (Cu, Zn, Ni, Mn, Mo) → Zinc
  • Groups of genes → Membrane proteins

    • Gene

    Coordinates
    310,000 → 310,842

    Phenotypes of a mutant

  • reduced genetic competence, can be rescued by the addition of excess zinc PubMed
  • reduced expression of the comFA-comFB-comFC-yvyF-flgM-yvyG-flgK-flgL operon PubMed

    • The protein

    Protein family

  • ABC-3 integral membrane protein family (according to Swiss-Prot)

    • Localization

  • cell membrane (according to UniProt)

    • Expression and Regulation

    Operons

    Genes
    znuA-znuC-znuB
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulatory mechanism

  • Zur: repression, in the presence of zinc PubMed, in Zur regulon

    • Regulation

  • induced by zinc starvation (Zur) PubMed
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    Biological materials

    Mutant

  • MGNA-B982 (yceA::erm), available at the NBRP B. subtilis, Japan
  • BKE02870 (ΔznuB::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGACGGCGATCATGCCGC, downstream forward: _UP4_TAACATGAAAAGCAGTTTTC
  • BKK02870 (ΔznuB::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGACGGCGATCATGCCGC, downstream forward: _UP4_TAACATGAAAAGCAGTTTTC

    • References

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